@article{MohrHendersonDudusetal.2004,
  author    = {A. Mohr and G. Henderson and L. Dudus and I. Herr and T. Kuerschner and K-M Debatin and H. Weiher and K. J. Fisher and R. M. Zwacka},
  title     = {AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression},
  series   = {Gene Ther. (Gene Therapy)},
  volume    = {11},
  publisher = {Nature Publishing Group},
  issn      = {0969-7128},
  doi       = {10.1038/sj.gt.3302154},
  pages     = {534 -- 543},
  year      = {2004},
  abstract  = {Gene transfer vectors based on the adeno-associated virus (AAV) are used for various experimental and clinical therapeutic approaches. In the present study, we demonstrate the utility of rAAV as a tumoricidal agent in human colorectal cancer. We constructed an rAAV vector that expresses tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) and used it to transduce human colorectal cancer cells. TRAIL belongs to the TNF superfamily of cytokines that are involved in various immune responses and apoptotic processes. It has been shown to induce cell death specifically in cancer cells.},
  language  = {en}
}