@article{AlthausLawong2022,
  author    = {Mike Althaus and Rene Yufenyuy Lawong},
  title     = {Proteolytic ENaC activation in health and disease—a complicated puzzle},
  series   = {Pfl{\"u}gers Archiv: European Journal of Physiology},
  volume    = {474},
  number    = {2},
  publisher = {Springer},
  issn      = {1432-2013},
  doi       = {10.1007/s00424-021-02644-w},
  url       = {https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-60084},
  pages     = {177 -- 179},
  year      = {2022},
  abstract  = {The epithelial sodium channel (ENaC) is a heterotrimeric ion channel that plays a key role in sodium and water homeostasis in tetrapod vertebrates. In the aldosterone-sensitive distal nephron, hormonally controlled ENaC expression matches dietary sodium intake to its excretion. Furthermore, ENaC mediates sodium absorption across the epithelia of the colon, sweat ducts, reproductive tract, and lung. ENaC is a constitutively active ion channel and its expression, membrane abundance, and open probability (PO) are controlled by multiple intracellular and extracellular mediators and mechanisms [9]. Aberrant ENaC regulation is associated with severe human diseases, including hypertension, cystic fibrosis, pulmonary edema, pseudohypoaldosteronism type 1, and nephrotic syndrome [9].},
  language  = {en}
}