TY - CHAP U1 - Konferenzveröffentlichung A1 - Witzler, Markus A1 - Gericke, Martin A1 - Heinze, Thomas A1 - Ottensmeyer, Patrick A1 - Tobiasch, Edda A1 - Schulze, Margit T1 - Novel hybrid agarose hydrogels for bone tissue engineering and drug delivery T2 - 5th EPNOE International Polysaccharide Conference, 20–24 AUGUST 2017, Jena, Germany. Abstract book N2 - Recent approaches in scaffold engineering for bone defects feature hybrid hydrogels made of a polymeric network (retains water and provides light and porous structures) and inorganic ceramics (add mechanical strength and improve cell-adhesion). Innovative scaffold materials should also induce bone tissue formation and incorporation of stem cells (osteogenic differentiation) and/or growth factors (inducing/supporting differentiation). Recently, purinergic P2X and P2Y receptors have been found to significantly influence the osteogenic differentiation process of human mesenchymal stem cells (hMSC). (1) Aim of this work is to develop polysaccharide (PS) composites to be used as scaffolds containing complementary receptor ligands to enable guided stem cell differentiation towards bone formation. Y1 - 2017 SP - 100 ER -