TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Götz, Werner
A1  - Tobiasch, Edda
A1  - Witzleben, Steffen
A1  - Schulze, Margit
T1  - Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
JF  - Pharmaceutics
N2  - Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-44313
SN  - 1999-4923
SS  - 1999-4923
U6  - https://doi.org/10.3390/pharmaceutics11030117
DO  - https://doi.org/10.3390/pharmaceutics11030117
PM  - 30871062
VL  - 11
IS  - 3
SP  - 27
S1  - 27
PB  - MDPI
CY  - Basel
ER  -