TY - THES U1 - Dissertation oder Habilitation A1 - Breuer, Christian T1 - Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins N2 - The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively. Y2 - 2020 UR - https://nbn-resolving.org/urn:nbn:de:hbz:5-57228 SP - VIII, 294 S1 - VIII, 294 PB - Universitäts- und Landesbibliothek Bonn ER -