TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Shoushrah, Sarah Hani
A1  - Transfeld, Janis Lisa
A1  - Tonk, Christian Horst
A1  - Büchner, Dominik
A1  - Witzleben, Steffen
A1  - Sieber, Martin A.
A1  - Schulze, Margit
A1  - Tobiasch, Edda
T1  - Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration
JF  - International Journal of Molecular Sciences
N2  - Dental stem cells have been isolated from the medical waste of various dental tissues. They have been characterized by numerous markers, which are evaluated herein and differentiated into multiple cell types. They can also be used to generate cell lines and iPSCs for long-term in vitro research. Methods for utilizing these stem cells including cellular systems such as organoids or cell sheets, cell-free systems such as exosomes, and scaffold-based approaches with and without drug release concepts are reported in this review and presented with new pictures for clarification. These in vitro applications can be deployed in disease modeling and subsequent pharmaceutical research and also pave the way for tissue regeneration. The main focus herein is on the potential of dental stem cells for hard tissue regeneration, especially bone, by evaluating their potential for osteogenesis and angiogenesis, and the regulation of these two processes by growth factors and environmental stimulators. Current in vitro and in vivo publications show numerous benefits of using dental stem cells for research purposes and hard tissue regeneration. However, only a few clinical trials currently exist. The goal of this review is to pinpoint this imbalance and encourage scientists to pick up this research and proceed one step further to translation.
KW  - hypoxia
KW  - iPSCs
KW  - dental stem cells immortalization
KW  - scaffolds
KW  - growth factors
KW  - bone tissue engineering
KW  - angiogenesis
KW  - organoids
KW  - drug release
KW  - osteogenesis
KW  - low-level laser therapy
KW  - dental stem cells
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-55476
SN  - 1422-0067
SS  - 1422-0067
U6  - https://doi.org/10.3390/ijms22126387
DO  - https://doi.org/10.3390/ijms22126387
PM  - 34203719
VL  - 22
IS  - 12
SP  - 61
S1  - 61
PB  - MDPI
CY  - Basel
ER  -