TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Roeth, Anjali A.
A1  - Garretson, Ian
A1  - Beltz, Maja
A1  - Herbold, Till
A1  - Schulze-Hagen, Maximilian
A1  - Quaisser, Sebastian
A1  - Georgens, Alex
A1  - Reith, Dirk
A1  - Slabu, Ioana
A1  - Klink, Christian D.
A1  - Neumann, Ulf P.
A1  - Linke, Barbara S.
T1  - 3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
JF  - Cancers
N2  - Animal models are often needed in cancer research but some research questions may be answered with other models, e.g., 3D replicas of patient-specific data, as these mirror the anatomy in more detail. We, therefore, developed a simple eight-step process to fabricate a 3D replica from computer tomography (CT) data using solely open access software and described the method in detail. For evaluation, we performed experiments regarding endoscopic tumor treatment with magnetic nanoparticles by magnetic hyperthermia and local drug release. For this, the magnetic nanoparticles need to be accumulated at the tumor site via a magnetic field trap. Using the developed eight-step process, we printed a replica of a locally advanced pancreatic cancer and used it to find the best position for the magnetic field trap. In addition, we described a method to hold these magnetic field traps stably in place. The results are highly important for the development of endoscopic tumor treatment with magnetic nanoparticles as the handling and the stable positioning of the magnetic field trap at the stomach wall in close proximity to the pancreatic tumor could be defined and practiced. Finally, the detailed description of the workflow and use of open access software allows for a wide range of possible uses.
KW  - models
KW  - pancreatic cancer
KW  - replica
KW  - digital manufacturing
KW  - endoscopy
KW  - magnetic nanoparticles
KW  - 3D printing
KW  - magnetic hyperthermia
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-59833
SN  - 2072-6694
SS  - 2072-6694
U6  - https://doi.org/10.3390/cancers13215496
DO  - https://doi.org/10.3390/cancers13215496
PM  - 34771659
VL  - 13
IS  - 21
SP  - 17
S1  - 17
PB  - MDPI
CY  - Basel
ER  -