TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Althaus, Mike
A1  - Lawong, Rene Yufenyuy
T1  - Proteolytic ENaC activation in health and disease—a complicated puzzle
JF  - Pflügers Archiv: European Journal of Physiology
N2  - The epithelial sodium channel (ENaC) is a heterotrimeric ion channel that plays a key role in sodium and water homeostasis in tetrapod vertebrates. In the aldosterone-sensitive distal nephron, hormonally controlled ENaC expression matches dietary sodium intake to its excretion. Furthermore, ENaC mediates sodium absorption across the epithelia of the colon, sweat ducts, reproductive tract, and lung. ENaC is a constitutively active ion channel and its expression, membrane abundance, and open probability (PO) are controlled by multiple intracellular and extracellular mediators and mechanisms [9]. Aberrant ENaC regulation is associated with severe human diseases, including hypertension, cystic fibrosis, pulmonary edema, pseudohypoaldosteronism type 1, and nephrotic syndrome [9].
Y1  - 2022
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-60084
SN  - 1432-2013
SS  - 1432-2013
U6  - https://doi.org/10.1007/s00424-021-02644-w
DO  - https://doi.org/10.1007/s00424-021-02644-w
PM  - 34799769
N1  - This article is a commentary to the original article https://doi.org/10.1007/s00424-021- 02639-7
VL  - 474
IS  - 2
SP  - 177
EP  - 179
PB  - Springer
ER  -