TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Condic, Mateja
A1  - Neidhöfer, Claudio
A1  - Ralser, Damian J.
A1  - Wetzig, Nina
A1  - Thiele, Ralf
A1  - Sieber, Martin
A1  - Otten, Lucia A.
A1  - Warwas, Leonie K.
A1  - Hoerauf, Achim
A1  - Mustea, Alexander
A1  - Parčina, Marijo
T1  - Analysis of the cervical microbiome in women from the German national cervical cancer screening program
JF  - Journal of Cancer Research and Clinical Oncology
N2  - PURPOSE
Cervical cancer (CC) is caused by a persistent high-risk human papillomavirus (hrHPV) infection. The cervico-vaginal microbiome may influence the development of (pre)cancer lesions. Aim of the study was (i) to evaluate the new CC screening program in Germany for the detection of high-grade CC precursor lesions, and (ii) to elucidate the role of the cervico-vaginal microbiome and its potential impact on cervical dysplasia.
METHODS
The microbiome of 310 patients referred to colposcopy was determined by amplicon sequencing and correlated with clinicopathological parameters.
RESULTS
Most patients were referred for colposcopy due to a positive hrHPV result in two consecutive years combined with a normal PAP smear. In 2.1% of these cases, a CIN III lesion was detected. There was a significant positive association between the PAP stage and Lactobacillus vaginalis colonization and between the severity of CC precursor lesions and Ureaplasma parvum.
CONCLUSION
In our cohort, the new cervical cancer screening program resulted in a low rate of additional CIN III detected. It is questionable whether these cases were only identified earlier with additional HPV testing before the appearance of cytological abnormalities, or the new screening program will truly increase the detection rate of CIN III in the long run. Colonization with U. parvum was associated with histological dysplastic lesions. Whether targeted therapy of this pathogen or optimization of the microbiome prevents dysplasia remains speculative.
KW  - Cervical cancer screening
KW  - Colposcopy
KW  - HPV diagnostic
KW  - Cervicovaginal microbiome
Y1  - 2023
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-66298
SN  - 0171-5216
SS  - 0171-5216
U6  - https://doi.org/10.1007/s00432-023-04599-0
DO  - https://doi.org/10.1007/s00432-023-04599-0
PM  - 36780053
VL  - 149
IS  - 9
SP  - 6489
EP  - 6500
PB  - Springer
ER  -