TY - JOUR U1 - Wissenschaftlicher Artikel A1 - Althaus, Mike A1 - Clauss, Wolfgang G. A1 - Fronius, Martin T1 - Amiloride-sensitive sodium channels and pulmonary edema JF - Pulmonary Medicine N2 - The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance. An important mechanism regulating alveolar fluid clearance is sodium transport across the alveolar epithelium. Transepithelial sodium transport is largely dependent on the activity of sodium channels in alveolar epithelial cells. This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. Furthermore, sodium channels as putative molecular targets for the treatment of pulmonary edema are discussed. Y1 - 2011 SN - 2090-1836 SS - 2090-1836 U6 - https://doi.org/10.1155/2011/830320 DO - https://doi.org/10.1155/2011/830320 PM - 21637371 VL - 2011 SP - 1 S1 - 1 PB - Hindawi ER -