TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Hinz, Jana
A1  - Mekonnen, Tessema F.
A1  - Bergrath, Jonas
A1  - Sewell, Savanna
A1  - Schneck, Yannic
A1  - Wirtz, Michaela
A1  - Telgheder, Ursula
T1  - Analysis of nine nitrosamines relevant to occupational safety by ion mobility spectroscopy and preliminary gas chromatographic separation
JF  - Journal of Chromatography Open
N2  - Nitrosamines have been identified as a probable human carcinogen and thus are of high concern in many manufacturing industries and various matrices (for example pharmaceutical, cosmetic and food products, workplace air or potable- and wastewater). This study aims to analyse nine nitrosamines relevant in the field of occupational safety using a gas chromatography-drift tube ion mobility spectrometry (GC-DT-IMS) system. To do this, single nitrosamine standards as well as a standard mix, each at 0.1 g/L, were introduced via liquid injection. A GC-DT-IMS method capable of separating the nitrosamine signals according to retention time (first dimension) and drift time (second dimension) in 10 min was developed. The system shows excellent selectivity as each nitrosamine gives two signals pertaining to monomer and dimer in the second dimension. For the first time, reduced ion mobility values for nitrosamines were determined, ranging from 1.18 to 2.03 cm2s−1V−1. The high selectivity of the GC-DT-IMS method could provide a definite advantage for monitoring nitrosamines in different manufacturing industries and consumer products.
KW  - Carcinogenic
KW  - Gas chromatography
KW  - Occupational safety
KW  - Drift tube
KW  - Nitrosamine
KW  - Ion mobility spectrometer
Y1  - 2023
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-75166
SN  - 2772-3917
SS  - 2772-3917
U6  - https://doi.org/10.1016/j.jcoa.2023.100102
DO  - https://doi.org/10.1016/j.jcoa.2023.100102
VL  - 4
SP  - 7
S1  - 7
PB  - Elsevier
ER  -