TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Kraus, Dominik
A1  - Glassmann, Alexander
A1  - Golletz, Carsten
A1  - Kristiansen, Glen
A1  - Winter, Jochen
A1  - Probstmeier, Rainer
T1  - Zona Pellucida Protein 2 (ZP2) Is Expressed in Colon Cancer and Promotes Cell Proliferation
JF  - Cancers
N2  - Our study shows ZP2 to be a new biomarker for diagnosis, best used in combination with other low abundant genes in colon cancer. Furthermore, ZP2 promotes cell proliferation via the ERK1/2-cyclinD1-signaling pathway. We demonstrate that ZP2 mRNA is expressed in a low-abundant manner with high specificity in subsets of cancer cell lines representing different cancer subtypes and also in a significant proportion of primary colon cancers. The potential benefit of ZP2 as a biomarker is discussed. In the second part of our study, the function of ZP2 in cancerogenesis has been analyzed. Since ZP2 shows an enhanced transcript level in colon cancer cells, siRNA experiments have been performed to verify the potential role of ZP2 in cell proliferation. Based on these data, ZP2 might serve as a new target molecule for cancer diagnosis and treatment in respective cancer types such as colon cancer.
KW  - molecular pathology
KW  - neoexpression
KW  - tumor diagnosis
KW  - cancer biomarker
KW  - zona pellucida protein 2 ZP2
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-53783
SN  - 2072-6694
SS  - 2072-6694
U6  - https://doi.org/10.3390/cancers13081759
DO  - https://doi.org/10.3390/cancers13081759
PM  - 33917056
VL  - 13
IS  - 8
SP  - 16
S1  - 16
PB  - MDPI
CY  - Basel
ER  -