TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Connolly, Patrick F. A1 - Jäger, Richard A1 - Fearnhead, Howard O. T1 - New roles for old enzymes: killer caspases as the engine of cell behavior changes JF - Frontiers in Physiology N2 - It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge. KW - caspase KW - apoptosis KW - myogenesis KW - proliferation KW - differentiation KW - non-apoptotic roles UN - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-13374 SN - 1664-042X SS - 1664-042X U6 - https://doi.org/10.3389/fphys.2014.00149 DO - https://doi.org/10.3389/fphys.2014.00149 PM - 24795644 VL - 5 SP - 10 S1 - 10 PB - Frontiers Media CY - Lausanne ER -