TY  - JOUR
A1  - Connolly, Patrick F.
A1  - Jäger, Richard
A1  - Fearnhead, Howard O.
T1  - New roles for old enzymes: killer caspases as the engine of cell behavior changes
T2  - Frontiers in Physiology
N2  - It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
KW  - caspase
KW  - apoptosis
KW  - myogenesis
KW  - proliferation
KW  - differentiation
KW  - non-apoptotic roles
Y1  - 2014
UR  - https://pub.h-brs.de/frontdoor/index/index/docId/1337
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-13374
SN  - 1664-042X
N1  - Copyright © 2014 Connolly, Jäger and Fearnhead. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
VL  - 5
SP  - 149
PB  - Frontiers Media
CY  - Lausanne
ER  -