@article{GoetzTobiaschWitzlebenetal.2019,
  author    = {Werner G{\"o}tz and Edda Tobiasch and Steffen Witzleben and Margit Schulze},
  title     = {Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation},
  series   = {Pharmaceutics},
  volume    = {11},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1999-4923},
  doi       = {10.3390/pharmaceutics11030117},
  url       = {https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-44313},
  year      = {2019},
  abstract  = {Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.},
  language  = {en}
}