@phdthesis{Breuer2020, author = {Christian Breuer}, title = {Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins}, pages = {VIII, 294}, year = {2020}, abstract = {The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.}, language = {en} }