TY  - THES
U1  - Dissertation / Habilitation
A1  - Breuer, Christian
T1  - Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
N2  - The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:5-57228
SP  - VIII, 294
S1  - VIII, 294
ER  -