TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Babczyk, Patrick A1 - Conzendorf, Clelia A1 - Klose, Jens A1 - Schulze, Margit A1 - Harre, Kathrin A1 - Tobiasch, Edda T1 - Stem Cells on Biomaterials for Synthetic Grafts to Promote Vascular Healing JF - Journal of Clinical Medicine N2 - This review is divided into two interconnected parts, namely a biological and a chemical one. The focus of the first part is on the biological background for constructing tissue-engineered vascular grafts to promote vascular healing. Various cell types, such as embryonic, mesenchymal and induced pluripotent stem cells, progenitor cells and endothelial- and smooth muscle cells will be discussed with respect to their specific markers. The in vitro and in vivo models and their potential to treat vascular diseases are also introduced. The chemical part focuses on strategies using either artificial or natural polymers for scaffold fabrication, including decellularized cardiovascular tissue. An overview will be given on scaffold fabrication including conventional methods and nanotechnologies. Special attention is given to 3D network formation via different chemical and physical cross-linking methods. In particular, electron beam treatment is introduced as a method to combine 3D network formation and surface modification. The review includes recently published scientific data and patents which have been registered within the last decade. KW - blood vessel KW - smooth muscle cell KW - stem cell KW - biomaterial KW - cross-linking KW - scaffold KW - endothelial cell KW - surface modification KW - collagen KW - biopolymer UN - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-14871 SN - 2077-0383 SS - 2077-0383 U6 - https://doi.org/10.3390/jcm3010039 DO - https://doi.org/10.3390/jcm3010039 PM - 26237251 VL - 3 IS - 1 SP - 39 EP - 87 PB - MDPI CY - Basel ER -