TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Schöndorf, Thomas
A1  - Eisele, Lewin
A1  - Göhring, Uwe-Jochen
A1  - Valter, Markus M.
A1  - Warm, Mathias
A1  - Mallmann, Peter
A1  - Becker, Martina
A1  - Fechteler, Roland
A1  - Weisshaar, Maria-Paz
A1  - Hoopmann, Markus
T1  - The V109G Polymorphism of the p27 Gene CDKN1B Indicates a Worse Outcome in Node-Negative Breast Cancer Patients
JF  - Tumor Biology
N2  - Although p27 plays a central role in cell cycle regulation, its role in breast cancer prognosis is controversial. Furthermore, the p27 gene CDKN1B carries a polymorphism with unknown functional relevance. This study was designed to evaluate p27 expression and p27 genotyping with respect to early breast cancer prognosis. 279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry. From 108 patients, the CDKN1B genotype was examined by PCR and subsequent direct sequencing. 55.2% of the tumors were considered p27 positive. p27 expression did not correlate with any of the established parameters except for nodal involvement but significantly correlated to prolonged disease-free survival. In 35% of the tumors analyzed, the CDKN1B gene showed a polymorphism at codon 109 (V109G). The V109G polymorphism correlated with greater nodal involvement. In the node-negative subgroup, V109G correlated significantly with a shortened disease-free survival. In conclusion, the determination of the CDKN1B genotype might be a powerful tool for the prognosis of patients with early breast cancer.
KW  - Breast cancer
KW  - CDKN1B
KW  - Chemotherapy
KW  - Node involvement
KW  - p27
KW  - Polymorphism
KW  - Prognosis
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-2219
SN  - 1010-4283
SS  - 1010-4283
U6  - https://doi.org/10.1159/000081396
DO  - https://doi.org/10.1159/000081396
PM  - 15627896
VL  - 25
IS  - 5-6
SP  - 306
EP  - 312
PB  - Karger
CY  - Basel
ER  -