TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Esser, Laura
A1  - Weiher, Hans
A1  - Schmidt-Wolf, Ingo
T1  - Increased Efficacy of Brentuximab Vedotin (SGN-35) in Combination with Cytokine-Induced Killer Cells in Lymphoma
JF  - International Journal of Molecular Sciences
N2  - Brentuximab vedotin (SGN-35) is an antibody–drug conjugate with a high selectivity against CD30+ cell lines and more than 300-fold less activity against antigen-negative cells. In the last years, the results of many in vitro and in vivo studies have led to the fast approval of this drug to treat lymphoma patients. Another innovative method to treat tumor cells including lymphoma cells is the use cytokine-induced killer (CIK) cells, which have also been approved and proven to be a safe treatment with only minor adverse events. In this study, a possible additive effect when combining SGN-35 with CIK cells was investigated. The combinational treatment showed that it reduces the viability of CD30+ cell lines significantly in vitro. Additionally, the amount of lymphoma cells was significantly reduced when exposed to CIK cells as well as when exposed to SGN-35. A significant negative effect of SGN-35 on the function of CIK cells could be excluded. These results lead to the assumption that SGN-35 and CIK cells in combination might achieve better results in an in vitro setting compared to the single use of SGN-35 and CIK cells. Further investigations in in vivo models must be conducted to obtain a better understanding of the exact mechanisms of both treatments when applied in combination.
KW  - cytokine-induced killer (CIK) cells
KW  - antibody–drug conjugate
KW  - lymphoma
KW  - SGN-35
KW  - CD30+ cells
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-25300
SN  - 1422-0067
SS  - 1422-0067
U6  - https://doi.org/10.3390/ijms17071056
DO  - https://doi.org/10.3390/ijms17071056
PM  - 27376285
VL  - 17
IS  - 7
PB  - MDPI
CY  - Basel
ER  -