TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Rajasekaran, Narendiran
A1  - Illges, Harald
T1  - Matrix Metalloproteinase MMP-9 Promotes K/BxN Serum Induced Arthritis in Mice
JF  - Open Journal of Rheumatology and Autoimmune Diseases
N2  - Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.
KW  - Gelatin Zymography
KW  - K/BxN
KW  - Antibody Induced Arthritis
KW  - MMP-9
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-22932
SN  - 2163-9914
SS  - 2163-9914
U6  - https://doi.org/10.4236/ojra.2014.41003
DO  - https://doi.org/10.4236/ojra.2014.41003
VL  - 4
IS  - 1
SP  - 22
EP  - 28
PB  - Scientific Research Publishing
ER  -