TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - McGrath, Eoghan A1 - Logue, Susan A1 - Mnich, Katarzyna A1 - Deegan, Shane A1 - Jäger, Richard A1 - Gorman, Adrienne A1 - Samali, Afshin T1 - The Unfolded Protein Response in Breast Cancer JF - Cancers N2 - In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required. A cell-stress response pathway, the unfolded protein response (UPR), has emerged as a promising target for the development of novel breast cancer treatments. This pathway is activated in response to a disturbance in endoplasmic reticulum (ER) homeostasis but has diverse physiological and disease-specific functions. In breast cancer, UPR signalling promotes a malignant phenotype and can confer tumours with resistance to widely used therapies. Here, we review several roles for UPR signalling in breast cancer, highlighting UPR-mediated therapy resistance and the potential for targeting the UPR alone or in combination with existing therapies. KW - autophagy KW - cell death KW - therapy KW - unfolded protein response (UPR) KW - breast cancer KW - endoplasmic reticulum (ER) stress UN - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-40650 SN - 2072-6694 SS - 2072-6694 U6 - https://doi.org/10.3390/cancers10100344 DO - https://doi.org/10.3390/cancers10100344 PM - 30248920 VL - 10 IS - 10 PB - MDPI CY - Basel ER -