TY  - JOUR
A1  - Eckert, Dawid
A1  - Buhl, Sandra
A1  - Weber, Susanne
A1  - Jäger, Richard
A1  - Schorle, Hubert
T1  - The AP-2 family of transcription factors
T2  - Genome Biol. (Genome Biology)
N2  - The AP-2 family of transcription factors consists of five different proteins in humans and mice: AP-2alpha, AP-2beta, AP-2gamma, AP-2delta and AP-2epsilon. Frogs and fish have known orthologs of some but not all of these proteins, and homologs of the family are also found in protochordates, insects and nematodes. The proteins have a characteristic helix-span-helix motif at the carboxyl terminus, which, together with a central basic region, mediates dimerization and DNA binding. The amino terminus contains the transactivation domain. AP-2 proteins are first expressed in primitive ectoderm of invertebrates and vertebrates; in vertebrates, they are also expressed in the emerging neural-crest cells, and AP-2alpha-/- animals have impairments in neural-crest-derived facial structures. AP-2beta is indispensable for kidney development and AP-2gamma is necessary for the formation of trophectoderm cells shortly after implantation; AP-2alpha and AP-2gamma levels are elevated in human mammary carcinoma and seminoma. The general functions of the family appear to be the cell-type-specific stimulation of proliferation and the suppression of terminal differentiation during embryonic development.
Y1  - 2005
UR  - https://pub.h-brs.de/frontdoor/index/index/docId/3749
SN  - 1474-760X
VL  - 6
IS  - 13
SP  - 246
PB  - BioMed Central
ER  -