TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Schorr, Kristel
A1  - Li, Minglin
A1  - Bar-Peled, Ud
A1  - Lewis, Albert
A1  - Heredia, Alonso
A1  - Lewis, Bernadette
A1  - Knudson, C. Michael
A1  - Korsmeyer, Stanley J.
A1  - Jäger, Richard
A1  - Weiher, Hans
A1  - Furth, Priscilla A.
T1  - Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo
JF  - Cancer Research
N2  - The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.
UR  - https://aacrjournals.org/cancerres/article/59/11/2541/505136
SN  - 1538-7445
SS  - 1538-7445
VL  - 59
IS  - 11
SP  - 2541
EP  - 2545
PB  - American Association for Cancer Research
ER  -