@incollection{Tobiasch2009,
  author    = {Edda Tobiasch},
  title     = {Adult Human Mesenchymal Stem Cells as Source for Future Tissue Engineering},
  series = {Zacharias, terHorst et al. (Hg.): Forschungsspitzen und Spitzenforschung. Innovationen an der FH Bonn-Rhein-Sieg, Festschrift f{\"u}r Wulf Fischer},
  publisher = {Physica-Verlag},
  address   = {Heidelberg},
  isbn      = {978-3-7908-2126-0},
  doi       = {10.1007/978-3-7908-2127-7\_29},
  pages     = {329 -- 338},
  year      = {2009},
  abstract  = {Embryonic stem cells (ES) have the potential of long-term viability, selfrenewal and pluripotency which makes them interesting candidates for tissue engineering and gene therapy applications. On the other hand ethical and political issues arise while using theses cells and severe problems such as their tumorgenicity have not been solved yet. In the last couple of month a new source of cells with stem cell character was developed, the induced pluripotent stem cells (iPS). These cells are derived from differentiated adult cells via transduction of three transcription factors and show features similar to embryonic stem cells. Unfortunately, this includes the tumorgenicity which is even higher in those cells since the transcription factor transduction needed until now, is performed with retrovial vectors, which have a tumor potential on their own. Thus, adult stem cells are investigated extensively as alternative source of self-renewing cells. Human mesenchymal stem cells (HMSCs), which have in addition the advantage of potential autologous transplantation, can be found in various differentiated tissues since they are needed for maintenance and repair. They can be differentiated in chondrogenic, osteogenic, adipogenic and myogenic lineages which makes them an excellent tool for future tissue replacement strategies.},
  language  = {en}
}