@article{SchorrLiBar-Peledetal.1999, author = {Schorr, Kristel and Li, Minglin and Bar-Peled, Ud and Lewis, Albert and Heredia, Alonso and Lewis, Bernadette and Knudson, C. Michael and Korsmeyer, Stanley J. and J{\"a}ger, Richard and Weiher, Hans and Furth, Priscilla A.}, title = {Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo}, journal = {Cancer Research}, volume = {59}, number = {11}, issn = {1538-7445}, url = {https://aacrjournals.org/cancerres/article/59/11/2541/505136}, institution = {Institut f{\"u}r funktionale Gen-Analytik (IFGA)}, pages = {2541 -- 2545}, year = {1999}, abstract = {The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50\% during the first stage and increased cell survival 70\% during the second stage. Complete loss of Bax reduced apoptosis by 20\% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.}, language = {en} }