TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Tonk, Christian Horst
A1  - Shoushrah, Sarah Hani
A1  - Babczyk, Patrick
A1  - El Khaldi-Hansen, Basma
A1  - Schulze, Margit
A1  - Herten, Monika
A1  - Tobiasch, Edda
T1  - Therapeutic Treatments for Osteoporosis-Which Combination of Pills Is the Best among the Bad?
JF  - International Journal of Molecular Sciences
N2  - Osteoporosis is a chronical, systemic skeletal disorder characterized by an increase in bone resorption, which leads to reduced bone density. The reduction in bone mineral density and therefore low bone mass results in an increased risk of fractures. Osteoporosis is caused by an imbalance in the normally strictly regulated bone homeostasis. This imbalance is caused by overactive bone-resorbing osteoclasts, while bone-synthesizing osteoblasts do not compensate for this. In this review, the mechanism is presented, underlined by in vitro and animal models to investigate this imbalance as well as the current status of clinical trials. Furthermore, new therapeutic strategies for osteoporosis are presented, such as anabolic treatments and catabolic treatments and treatments using biomaterials and biomolecules. Another focus is on new combination therapies with multiple drugs which are currently considered more beneficial for the treatment of osteoporosis than monotherapies. Taken together, this review starts with an overview and ends with the newest approaches for osteoporosis therapies and a future perspective not presented so far.
KW  - bone mineral density
KW  - Treatment
KW  - biomaterial
KW  - catabolic
KW  - bone remodeling
KW  - combination of treatments
KW  - anabolic
KW  - osteoblast
KW  - osteoclast
KW  - osteoporosis
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-61029
SN  - 1422-0067
SS  - 1422-0067
U6  - https://doi.org/10.3390/ijms23031393
DO  - https://doi.org/10.3390/ijms23031393
PM  - 35163315
VL  - 23
IS  - 3
SP  - 36
S1  - 36
PB  - MDPI
CY  - Basel
ER  -