TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Goonoo, Nowsheen
A1  - Laetitia Huët, Marie Andrea
A1  - Chummun, Itisha
A1  - Karuri, Nancy
A1  - Badu, Kingsley
A1  - Gimié, Fanny
A1  - Bergrath, Jonas
A1  - Schulze, Margit
A1  - Müller, Mareike
A1  - Bhaw-Luximon, Archana
T1  - Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis
JF  - Royal Society Open Science
N2  - Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Treatment of cutaneous leishmaniasis (CL) aims at accelerating wound healing, reducing scarring and cosmetic morbidity, preventing parasite transmission and relapse. Unfortunately, available treatments show only suboptimal effectiveness and none of them were designed specifically for this disease condition. Tissue regeneration using nano-based devices coupled with drug delivery are currently being used in clinic to address diabetic wounds. Thus, in this review, we analyse the current treatment options and attempt to critically analyse the use of nanomedicine-based strategies to address CL wounds in view of achieving scarless wound healing, targeting secondary bacterial infection and lowering drug toxicity.
KW  - tissue engineering
KW  - scaffolds
KW  - nanomedicine
KW  - drug delivery
KW  - leishmaniasis
UN  - https://nbn-resolving.org/urn:nbn:de:hbz:1044-opus-62791
SN  - 2054-5703
SS  - 2054-5703
U6  - https://doi.org/10.1098/rsos.220058
DO  - https://doi.org/10.1098/rsos.220058
PM  - 35719886
VL  - 9
IS  - 6
SP  - 28
S1  - 28
PB  - Royal Society
ER  -