Biology of the Endoplasmic Reticulum

  • Since its discovery in 1945, our knowledge of the structure and many functions of the endoplasmic reticulum (ER) has advanced at a phenomenal rate. Early studies focused on the structure, which was then followed by biochemical and functional studies associated with calcium storage and release from the ER, protein folding and secretion, ER associated degradation (ERAD) and ER stress responses. Currently there is a significant interest in the role of ER in such cellular processes as cell death, autophagy and cross-talk with other organelles. In this chapter we give an overview of the structural characteristics and biochemical functioning of the ER and describe its manifold roles in cellular physiology. Finally, we explain how the sensitive nature of the protein folding process in the ER enables this organelle to act as a sensor of a broad range of cellular stresses. Signals emanating from the stressed ER play central roles in differentiation processes, cellular homeostasis and cell death.

Export metadata

  • Export Bibtex
  • Export RIS

Additional Services

Share in Twitter Search Google Scholar Availability
Metadaten
Document Type:Part of a Book
Language:English
Parent Title (English):Agostinis, Afshin (Eds.): Endoplasmic Reticulum Stress in Health and Disease
First Page:3
Last Page:22
ISBN:978-94-007-4350-2
DOI:10.1007/978-94-007-4351-9_1
Publisher:Springer
Place of publication:Dordrecht
Date of first publication:2012/08/08
Tag:Calcium storage; ERAD; Endoplasmic reticulum; Golgi; Protein folding; apoptosis; autophagy; carbohydrate metabolism; cell stress; drug detoxification; glycosylation; lipid biosynthesis; membrane trafficking; physiology; protein secretion; unfolded protein response
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IfGA)
Dewey Decimal Classification (DDC):600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2018/07/14

$Rev: 12793 $