Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling

  • Specific neurosecretory cells of the Drosophila brain express insulin-like peptides (dilps), which regulate growth, glucose homeostasis, and aging. Through microarray analysis of flies in which the insulin-producing cells (IPCs) were ablated, we identified a target gene, target of brain insulin (tobi), that encodes an evolutionarily conserved alpha-glucosidase. Flies with lowered tobi levels are viable, whereas tobi overexpression causes severe growth defects and a decrease in body glycogen. Interestingly, tobi expression is increased by dietary protein and decreased by dietary sugar. This pattern is reminiscent of mammalian glucagon secretion, which is increased by protein intake and decreased by sugar intake, suggesting that tobi is regulated by a glucagon analog. tobi expression is also eliminated upon ablation of neuroendocrine cells that produce adipokinetic hormone (AKH), an analog of glucagon. tobi is thus a target of the insulin- and glucagon-like signaling system that responds oppositely to dietary protein and sugar.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Cell Metabolism
Volume:7
Issue:4
First Page:321
Last Page:332
ISSN:1550-4131
DOI:https://doi.org/10.1016/j.cmet.2008.02.012
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=18396138
Publisher:Cell Press
Place of publication:Cambridge, MA
Date of first publication:2008/04/08
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2019/02/26