Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

  • Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Pharmaceutics
Volume:11
Issue:3
First Page:117
ISSN:1999-4923
URN:urn:nbn:de:hbz:1044-opus-44313
DOI:https://doi.org/10.3390/pharmaceutics11030117
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30871062
Publisher:MDPI
Place of publication:Basel
Date of first publication:2019/03/12
Note:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2019/03/28
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International