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Testing of Pressure Sensitive Adhesives for Transdermal Therapeutic Systems

  • Traditional and newly developed testing methods were used for extensive application-related characterization of transdermal therapeutic systems (TTS) and pressure sensitive adhesives (PSA). Large amplitude oscillatory shear tests of PSAs were correlated to the material behavior during the patient’s motion and showed that all PSAs were located close to the gel point. Furthermore, an increasing strain amplitude results in stretching and yielding of the PSA´s microstructure causing a consolidation of the network and a release with increasing strain amplitude. RheoTack approach was developed to allow for an advanced tack characterization of TTS with visual inspection. The results showed a clear resin content and rod geometry dependent behavior, and displays the PSA´s viscoelasticity resulting in either high tack and long stretched fibrils or non-adhesion and brittle behavior. Moreover, diffusion of water / sweat during TTS´s application might influence its performance. Therefore, a dielectric analysis based evaluation method displayed occurring water diffusion into the PSA from which the diffusion coefficient can be determined, and showed clear material and resin content dependent behavior. All methods allow for an advanced product-oriented material testing that can be utilized within further TTS development.

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Metadaten
Document Type:Doctoral Thesis
Language:English
Author:Michael Meurer
Title translated (Czech):Testování adheziv v transdermálních terapeutických materiálech
ISBN:978-80-7678-230-3
URL:http://hdl.handle.net/10563/54629
Referee:Berenika Hausnerová, Bernhard Möginger
Place of publication:Zlin
Contributing Corporation:Tomas Bata University
Publication year:2024
Copyright:© Meurer, Michael
Keyword:adhesion; diffusion; pressure sensitive adhesives; rheology; transdermal therapeutic systems
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für Technik, Ressourcenschonung und Energieeffizienz (TREE)
Graduierteninstitut
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 53 Physik / 531 Klassische Mechanik; Festkörpermechanik
Entry in this database:2024/03/21