Decreased levels of sCD21 and sCD23 in blood of patients with systemic-juvenile arthritis, polyarticular-juvenile arthritis, and pauciarticular-juvenile arthritis

  • A soluble form of CD21 (sCD21) and CD23 (sCD23) is released from the surface of human white blood cells upon shedding of the extracellular domain. sCD21 circulates in a complex with cleavage fragments of C3 and sCD23, which were previously identified as ligands of membrane and soluble CD21. sCD21 seems to be a marker of chronic inflammatory disease. To assess the sCD21 and sCD23 status in patients with subsets of juvenile arthritis (JA), we determined plasma levels sCD21 and sCD23. Plasma sCD21 levels were significantly decreased in all JA subtypes (O-JA P < 0.0068; P- and S-JA P < 0.0001) compared to healthy controls. Plasma sCD23 levels were significantly decreased in P-JA and S-JA (both P < 0.0001), but not in O-JA (P < 0.3843) in comparison with healthy controls, and data statistically analyzed. Our results suggest that pathological mechanisms relevant to autoimmune disorders interfere with the regulation of both CD21 and CD23 shedding.

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Metadaten
Document Type:Article
Language:English
Author:Anjana Singh, Sebastiaan J. Vastert, Berent J. Prakken, Harald Illges
Parent Title (English):Rheumatol Int. (Rheumatology International)
Volume:32
Issue:6
First Page:1581
Last Page:1587
ISSN:0172-8172
DOI:https://doi.org/10.1007/s00296-011-1830-1
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=21328056
Publisher:Springer
Date of first publication:2011/02/17
Tag:Complement; Juvenile arthritis (JA); Soluble CD21; Soluble CD23
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2015/04/02