"Dead Cells Talking": The Silent Form of Cell Death Is Not so Quiet

  • After more than twenty years of research, the molecular events of apoptotic cell death can be succinctly stated; different pathways, activated by diverse signals, increase the activity of proteases called caspases that rapidly and irreversibly dismantle condemned cell by cleaving specific substrates. In this time the ideas that apoptosis protects us from tumourigenesis and that cancer chemotherapy works by inducing apoptosis also emerged. Currently, apoptosis research is shifting away from the intracellular events within the dying cell to focus on the effect of apoptotic cells on surrounding tissues. This is producing counterintuitive data showing that our understanding of the role of apoptosis in tumourigenesis and cancer therapy is too simple, with some interesting and provocative implications. Here, we will consider evidence supporting the idea that dying cells signal their presence to the surrounding tissue and, in doing so, elicit repair and regeneration that compensates for any loss of function caused by cell death. We will discuss evidence suggesting that cancer cell proliferation may be driven by inappropriate or corrupted tissue-repair programmes that are initiated by signals from apoptotic cells and show how this may dramatically modify how we view the role of apoptosis in both tumourigenesis and cancer therapy.

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Metadaten
Document Type:Article
Language:English
Author:Richard Jäger, Howard O. Fearnhead
Parent Title (English):Biochem Res Int. (Biochemistry Research International)
Volume:2012
Pagenumber:8
First Page:453838
ISSN:2090-2255
URN:urn:nbn:de:hbz:1044-opus-9505
DOI:https://doi.org/10.1155/2012/453838
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=22919490
Publisher:Hindawi
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2012/08/07
Note:
Copyright © 2012 Richard Jäger and Howard O. Fearnhead. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2015/04/02
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 3.0