Mechanisms Underlying the Osteo-and Adipo-Differentiation of Human Mesenchymal Stem Cells

  • Human mesenchymal stem cells (hMSCs) are considered a promising cell source for regenerative medicine, because they have the potential to differentiate into a variety of lineages among which the mesoderm-derived lineages such adipo- or osteogenesis are investigated best. Human MSCs can be harvested in reasonable to large amounts from several parts of the patient’s body and due to this possible autologous origin, allorecognition can be avoided. In addition, even in allogenic origin-derived donor cells, hMSCs generate a local immunosuppressive microenvironment, causing only a weak immune reaction. There is an increasing need for bone replacement in patients from all ages, due to a variety of reasons such as a new recreational behavior in young adults or age-related diseases. Adipogenic differentiation is another interesting lineage, because fat tissue is considered to be a major factor triggering atherosclerosis that ultimately leads to cardiovascular diseases, the main cause of death in industrialized countries. However, understanding the differentiation process in detail is obligatory to achieve a tight control of the process for future clinical applications to avoid undesired side effects. In this review, the current findings for adipo- and osteo-differentiation are summarized together with a brief statement on first clinical trials.

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Metadaten
Document Type:Article
Language:English
Author:Yu Zhang, Dilaware Khan, Julia Delling, Edda Tobiasch
Parent Title (English):The Scientific World Journal
Volume:2012
First Page:793823
ISSN:1537-744X
URN:urn:nbn:de:hbz:1044-opus-9596
DOI:https://doi.org/10.1100/2012/793823
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=22500143
Publisher:Hindawi
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2012/03/12
Note:
Copyright © 2012 Yu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2015/04/02
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 3.0