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Soluble CD21 in sera and synovial fluid of arthritic patients

  • Soluble CD21 (sCD21) is the ectodomain of the CD21 glycoprotein released by shedding from the cellular membrane. The ectodomain of CD21 is capable of binding complement fragments, Epstein-Barr virus (EBV) and CD23. Functionally sCD21 can activate monocytes and abrogate B-cell/follicular dendritic cell interaction, thereby inhibiting antibody production by antigen primed B cells. Levels of sCD21 vary in several clinical conditions. Here we analyzed sCD21 in synovial fluids and sera in arthritic patients. sCD21 concentrations were consistently lower in synovial fluids compared to paired sera samples from the same patients. In contrast to healthy donors, sCD21 levels are significantly reduced in rheumatoid arthritis patient's sera. Potential causes and consequences of the data are discussed.

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Document Type:Article
Author:Thomas Grottenthaler, Johannes von Kempis, Sigune Goldacker, Harald Illges
Parent Title (English):Rheumatol Int (Rheumatology International)
First Page:240
Last Page:243
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=15770483
Date of first publication:2005/03/16
Tag:Arthritis; CD21; Complement receptor 2; Shedding; Synovial fluid
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2018/06/06