CIK Cells and HDAC Inhibitors in Multiple Myeloma
- Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4-5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. This study investigated the impact of a combined treatment compared to treatment with histone deacetylase inhibitors. The experiments revealed that a treatment with histone deacetylase (HDAC) inhibitors could reduce cell viability to 59% for KMS 18 cell line and 46% for the U-266 cell line. The combined treatment led to a decrease of cell viability to 33% for KMS 18 and 27% for the U-266 cell line, thus showing a significantly better efficacy than the single treatment.
Document Type: | Article |
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Language: | English |
Author: | David Stephan, Hans Weiher, Ingo G. H. Schmidt-Wolf |
Parent Title (English): | International Journal of Molecular Sciences |
Volume: | 18 |
Issue: | 5 |
Article Number: | 945 |
ISSN: | 1422-0067 |
URN: | urn:nbn:de:hbz:1044-opus-30480 |
DOI: | https://doi.org/10.3390/ijms18050945 |
PMID: | https://pubmed.ncbi.nlm.nih.gov/28468247 |
Publisher: | MDPI |
Place of publication: | Basel |
Publishing Institution: | Hochschule Bonn-Rhein-Sieg |
Date of first publication: | 2017/04/29 |
Copyright: | © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
Keyword: | CIK cells; cancer treatment; cytokine-induced killer cells; histone deacetylase inhibitors; immunotherapy; multiple myeloma |
Departments, institutes and facilities: | Fachbereich Angewandte Naturwissenschaften |
Institut für funktionale Gen-Analytik (IFGA) | |
Dewey Decimal Classification (DDC): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Entry in this database: | 2017/05/11 |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |