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Utilizing ethacrynic acid and ciclopirox olamine in liver cancer

  • Once aberrantly activated, the Wnt/βcatenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against βcatenin, as it serves a role on the cytoplasm and the nucleus. In addition, speciallygenerated lymphocytes are recruited for the purpose of treating liver cancer. Peripheral blood mononuclear lymphocytes are expanded by the timely addition of interferon γ, interleukin (IL)1β, IL2 and anticluster of differentiation 3 antibody. The resulting cells are called cytokineinduced killer (CIK) cells. The present study utilised these cells and combine them with drugs inhibiting the Wnt pathway in order to examine whether this resulted in an improvement in the killing ability of CIK cells against liver cancer cells. Drugs including ethacrynic acid (EA) and ciclopirox olamine (CPX) were determined to be suitable candidates, as determined by previous studies. Drugs were administered on their own and combined with CIK cells and then a cell viability assay was performed. These results suggest that EAtreated cells demonstrated apoptosis and were significantly affected compared with untreated cells. Unlike EA, CPX killed normal and cancerous cells even at low concentrations. Subsequent to combining EA with CIK cells, the potency of killing was increased and a greater number of cells died, which proves a synergistic action. In summary, EA may be used as an antihepatocellular carcinoma drug, while CPX possesses a high toxicity to cancerous as well as to normal cells. It was proposed that EA should be integrated into present therapeutic methods for cancer.

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Metadaten
Document Type:Article
Language:English
Author:Ahmad M. Al‑Dali, Hans Weiher, Ingo G. H. Schmidt-Wolf
Parent Title (English):Oncol Lett. (Oncology Letters)
Volume:16
Issue:5
First Page:6854
Last Page:6860
ISSN:1792-1074
DOI:https://doi.org/10.3892/ol.2018.9472
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30405829
Publisher:Spandidos Publications
Date of first publication:2018/09/20
Tag:Wnt/β-catenin; ciclopirox olamine; cytokine-induced killer cells; ethacrynic acid; hepatocellular carcinoma; interferon γ
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IfGA)
Entry in this database:2018/09/22