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New roles for old enzymes: killer caspases as the engine of cell behavior changes

  • It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Front Physiol (Frontiers in Physiology)
Volume:5
First Page:149
ISSN:1664-042X
DOI:https://doi.org/10.3389/fphys.2014.00149
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24795644
Publisher:Frontiers Media
Place of publication:Lausanne
Date of first publication:2014/04/16
Note:
Copyright © 2014 Connolly, Jäger and Fearnhead. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Tag:apoptosis; caspase; differentiation; myogenesis; non-apoptotic roles; proliferation
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IfGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen
Entry in this database:2015/04/02
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International