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Protein threading by recursive dynamic programming

  • We present the recursive dynamic programming (RDP) method for the threading approach to three-dimensional protein structure prediction. RDP is based on the divide-and-conquer paradigm and maps the protein sequence whose backbone structure is to be found (the protein target) onto the known backbone structure of a model protein (the protein template) in a stepwise fashion, a technique that is similar to computing local alignments but utilising different cost functions.

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Metadaten
Document Type:Article
Language:English
Author:Ralf Thiele, Ralf Zimmer, Thomas Lengauer
Parent Title (English):J Mol Biol. (Journal of molecular biology)
Volume:290
Issue:3
First Page:757
Last Page:779
ISSN:0022-2836
DOI:https://doi.org/10.1006/jmbi.1999.2893
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=10395828
Publisher:Academic Press
Date of first publication:1999/07/16
Tag:Amino Acid Sequence; Databases, Factual; Molecular Sequence Data; Protein Conformation; Protein Folding; Proteins/chemistry; Sequence Homology, Amino Acid
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2015/09/09