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Azelaic Acid: Properties and Mode of Action

  • Acne is a common skin disorder that can be problematic for adults as well as for adolescents. It has several key pathophysiological features such as follicular hyperkeratosis, elevated Propionibacterium acnes proliferation, and reactive inflammation, all of which should be targeted for an optimal outcome. Azelaic acid (AzA) has profound anti-inflammatory, antioxidative effects, and is bactericidal against a range of Gram-negative and Gram-positive microorganisms as well, including antibiotic-resistant bacterial strains. In addition, AzA's antikeratinizing effects are inhibitory toward comedones. AzA is effective overall in targeting multiple causes of acne and has been proven to be well tolerated in numerous clinical trials.

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Metadaten
Document Type:Article
Language:English
Author:M. A. Sieber, J. K. E. Hegel
Parent Title (English):Skin Pharmacol Physiol. (Skin Pharmacology and Physiology)
Volume:27
Issue:Suppl 1
First Page:9
Last Page:17
ISSN:1660-5527
DOI:https://doi.org/10.1159/000354888
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24280644
Publisher:Karger
Publication year:2014
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IFGA)
Entry in this database:2018/08/08