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Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice

  • Mutations in inhibitory glycine receptor (GlyR) subunit genes are associated with neuromotor diseases in man and mouse. To use the potential of the mouse mutants as animal models of human disease, we altered GlyR levels in mutant mice and studied their phenotype. A transgene coding for the beta subunit of the rat GlyR was introduced into the genetic background of the spa mutation, which is characterized by low endogenous expression levels of the beta subunit and a dramatic neuromotor phenotype. The resulting transgenic mice expressed the beta subunit mRNA at intermediate levels, and their phenotype was rescued. This provides formal proof for the casual relationship between GlyR beta gene mutation and motor disease, and indicates that a low level of beta gene expression (25% of normal) is sufficient for proper functioning of glycinergic synapses.

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Metadaten
Document Type:Article
Language:English
Author:B. Hartenstein, J. Schenkel, J. Kuhse, B. Besenbeck, C. Kling, C. M. Becker, H. Betz, H. Weiher
Parent Title (English):EMBO J. (The EMBO Journal)
Volume:15
Issue:6
First Page:1275
Last Page:1282
ISSN:0261-4189
DOI:https://doi.org/10.1002/j.1460-2075.1996.tb00469.x
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=8635460
Publisher:EMBO Press
Publication year:1996
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2018/09/21