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D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4+ -T cells

  • The expression of dopamine receptors was examined in purified human neutrophils, monocytes, B cells, natural killer cells and CD4+ - and CD8+ -T lymphocytes by RT-PCR. In healthy subjects, D1 and D2 receptors were not expressed in leukocytes. Real Time PCR for dopamine receptors D3 and D4 disclosed that D3 receptors are expressed in T cells and natural killer cells and D4 receptors in CD4+ -T cells. The comparison of schizophrenic patients with sex- and age-matched controls revealed a significantly higher expression of D3 receptor mRNA in T cells of schizophrenic patients, whereas D4 receptor mRNA in CD4+ -T cells was downregulated.

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Metadaten
Document Type:Article
Language:English
Author:Eva-Maria Boneberg, Elisabeth von Seydlitz, Karl Pröpster, Hans Watzl, Brigitte Rockstroh, Harald Illges
Parent Title (English):J Neuroimmunol. (Journal of Neuroimmunology)
Volume:173
Issue:1-2
First Page:180
Last Page:187
ISSN:0165-5728
DOI:https://doi.org/10.1016/j.jneuroim.2005.11.018
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=16376996
Publisher:Elsevier
Date of first publication:2006/01/01
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2018/07/25