Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo
- The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.
Document Type: | Article |
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Language: | English |
Author: | Kristel Schorr, Minglin Li, Ud Bar-Peled, Albert Lewis, Alonso Heredia, Bernadette Lewis, C. Michael Knudson, Stanley J. Korsmeyer, Richard Jäger, Hans Weiher, Priscilla A. Furth |
Parent Title (English): | Cancer Research |
Volume: | 59 |
Issue: | 11 |
First Page: | 2541 |
Last Page: | 2545 |
ISSN: | 1538-7445 |
URL: | https://aacrjournals.org/cancerres/article/59/11/2541/505136 |
Publisher: | American Association for Cancer Research |
Date of first publication: | 1999/06/01 |
Departments, institutes and facilities: | Institut für funktionale Gen-Analytik (IFGA) |
Dewey Decimal Classification (DDC): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Entry in this database: | 2018/07/14 |