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The effect of nanostructured surfaces on stem cell fate

  • The ability of stem cells to self-renew and differentiate into multiple lineages has made them attractive candidates for therapeutic interventions. Adult stem cells are a promising source for regenerative medicine approaches since they are easy to obtain, and bear a lower risk of immune rejection and tumor formation, compared to embryonic stem cells or iPS cells. Controlling their fate tightly is still the key challenge on their way from bench to bedside use. While conventional methods are based mainly on chemical induction of differentiation via growth factors and cytokines, concentrating on altering material properties, such as substrate stiffness and topography, to mimic the stimuli stem cells receive in their natural niche gets more into focus recently. It has been shown that (nano)structural and mechanical triggers derived from the extracellular matrix can influence stem cell fate by promoting self-renewal or differentiation if tissue repair is needed. In this chapter, the chemical structure of various nanomaterials used as scaffolds for stem cell differentiation will be discussed, including bulk and surface properties and corresponding analytical methods for surface characterization. Furthermore, recently developed methods for the design of tailor-made nanomaterial used in stem cell differentiation will be discussed in the current chapter.

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Document Type:Part of a Book
Author:Dorothee Schipper, Patrick Babczyk, Fatma Elsayed, Stephanie E. Klein, Margit Schulze, Edda Tobiasch
Parent Title (English):Grumezescu, Ficai (Eds.): Nanostructures for Novel Therapy. Synthesis, Characterization and Applications
First Page:567
Last Page:589
Place of publication:Amsterdam
Date of first publication:2017/03/03
Tag:nanomaterials; nanostructured surfaces; regenerative medicine; stem cell niche; stem cells
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Entry in this database:2017/03/06