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Identification of TEL-AML1 (ETV6-RUNX1) associated DNA and its impact on mRNA and protein output using ChIP, mRNA expression arrays and SILAC

  • The contribution of the most common reciprocal translocation in childhood B-cell precursor leukemia t(12;21)(p13;q22) to leukemia development is still under debate. Direct as well as secondary indirect effects of the TEL-AML1 fusion protein are commonly recorded by using cell lines and patient samples, often bearing the TEL-AML1 fusion protein for decades. To identify direct targets of the fusion protein a short-term induction of TEL-AML1 is needed. We here describe in detail the experimental procedure, quality controls and contents of the ChIP, mRNA expression and SILAC datasets associated with the study published by Linka and colleagues in the Blood Cancer Journal [1] utilizing a short term induction of TEL-AML1 in an inducible precursor B-cell line model.

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Document Type:Article
Author:Yvonne Linka, Sebastian Ginzel, Arndt Borkhardt, Pablo Landgraf
Parent Title (English):Genomics Data
First Page:85
Last Page:88
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=26484077
Publishing Institution:Hochschule Bonn-Rhein-Sieg
Date of first publication:2014/05/27
© 2014 The Authors. This is an open access article under the CC BY-NC-SA license.
Tag:B-cell leukemia; ETV6-RUNX1; Genomics; TEL-AML1; Translocation
Departments, institutes and facilities:Fachbereich Informatik
Dewey Decimal Classification (DDC):5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 611 Menschliche Anatomie, Zytologie, Histologie
Entry in this database:2015/04/02
Licence (German):License LogoCreative Commons - CC BY-NC-SA - Namensnennung-Keine kommerzielle Nutzung-Weitergabe unter gleichen Bedingungen 3.0