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Mouse mammary gland involution is associated with cytochrome c release and caspase activation

  • At weaning, milk producing mammary epithelial cells undergo apoptosis and are removed by phagocytosis. Here, we show that mouse mammary gland involution is associated with mitochondrial cytochrome c release and processing of numerous caspases, including caspase-1, -3, -7, -8 and -9. Induction of caspase-3-like activity paralleled cleavage of poly-(ADP--ribose) polymerase. Dexamethasone inhibited processing of caspase-3, -7 and -8 and apoptosis, but had no effect on caspase-1 accumulation and cytochrome c release. In Bcl-2 transgenic animals, cytochrome c release, caspase activation and apoptosis were impaired. Thus, the pro-apoptotic signaling pathway in mammary epithelial cells during involution involves the release of cytochrome c and activation of caspases. It is inhibited by Bcl-2 at the mitochondrial level and by dexamethasone at a post-mitochondrial level.

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Metadaten
Document Type:Article
Language:English
Author:Andreas Marti, Philipp M. Ritter, Richard Jäger, Hedvika Lazar, Anna Baltzer, Johannes Schenkel, Wim Declercq, Peter Vandenabeele, Rolf Jaggi
Parent Title (English):Mech Dev. (Mechanisms of Development)
Volume:104
Issue:1-2
First Page:89
Last Page:98
ISSN:0925-4773
DOI:https://doi.org/10.1016/S0925-4773(01)00381-1
Publisher:Elsevier
Date of first publication:2001/06/06
Tag:Caspase; Cytochrome c; Involution; Programmed cell death; apoptosis
Departments, institutes and facilities:Institut für funktionale Gen-Analytik (IfGA)
Entry in this database:2018/07/14