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The role of the complement and the FcγR system in the pathogenesis of arthritis

  • Autoantibodies in sera from patients with autoimmune diseases have long been known and have become diagnostic tools. Analysis of their functional role again became popular with the availability of mice mutant for several genes of the complement and Fcγ receptor (FcγR) systems. Evidence from different inflammatory models suggests that both systems are interconnected in a hierarchical way. The complement system mediators such as complement component 5a (C5a) might be crucial in the communication between the complement system and FcγR-expressing cells. The split complement protein C5a is known to inactivate cells by its G-protein-coupled receptor and to be involved in the transcriptional regulation of FcγRs, thereby contributing to the complex regulation of autoimmune disease.

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Metadaten
Document Type:Article
Language:English
Author:Samuel Solomon, Daniela Kassahn, Harald Illges
Parent Title (English):Arthritis Res Ther (Arthritis Research & Therapy)
Volume:7
Issue:4
First Page:129
Last Page:135
ISSN:1478-6354
DOI:https://doi.org/10.1186/ar1761
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=15987494
Publisher:BioMed Central
Date of first publication:2005/05/16
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Institut für funktionale Gen-Analytik (IFGA)
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2015/04/02