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Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

  • The prognosis of children with acute lymphoblastic leukemia (ALL) relapsing following allogeneic hematopoietic stem cell transplantation (allo-SCT) is still dismal. Within the framework of the ALL-REZ BFM 2002/ALL-SZT BFM 2003 trials, we performed whole-exome sequencing (WES) of ten patients relapsing after allo-SCT with the aim to thoroughly characterize the spectrum of acquired mutations and to identify potentially druggable targets, thus laying the ground for future personalized treatment strategies.

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Document Type:Article
Author:Jessica I. Hoell, Sebastian Ginzel, Cornelia Eckert, Michael Gombert, Ute Fischer, Martin Stanulla, Martin Schrappe, Udo Zur Stadt, Peter Bader, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend Stackelberg, Christina Peters, Arndt Borkhardt, Roland Meisel
Parent Title (English):Blood
First Page:601
Publisher:The American Society of Hematology
Date of first publication:2016/12/02
618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Relapsed ALL and Therapy Resistance, December 2, 2016
Departments, institutes and facilities:Fachbereich Informatik
Dewey Decimal Classification (DDC):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2016/12/15