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Differentiation Potential of Adult Human Mesenchymal Stem Cells

  • Human mesenchymal stem cells (HMSCs) which are isolated from bone marrow stroma, peripheral blood, dermis, muscle and adipose tissue have the advantage of potential autologous transplantation ability. They can be differentiated into chondrogenic, osteogenic, adipogenic and myogenic lineages. Problems of stem cells from bone marrow are low cell numbers, low isolated volumes, pain, and to some extent ethical concerns. The isolation of mesenchymal stem cells from human adipose tissue was recently identified as an alternative source, since these cells are easy to obtain in big cell numbers. Adipose tissue is derived from embryonic mesoderm and contains a heterogeneous stromal cell population. To achieve lineage-specific differentiation of these cells they have to be cultured in media supplemented with appropriate factors. Inductions of the cells into multiple mesenchymal lineages resulted in the expression of several lineage-specific genes, proteins and specific metabolic activity. In conclusion, the potential benefit of the multi-germline capacity of HMSCs seems to be a promising approach for allogenic cell therapy and human tissue engineering.

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Metadaten
Document Type:Article
Language:English
Parent Title (English):Clin Lab. (Clinical Laboratory)
Volume:53
Issue:1-2
First Page:81
Last Page:84
ISSN:1433-6510
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=17323830
Publisher:Clinical Laboratory Publications
Place of publication:Mainz
Publication year:2007
Tag:Adipose tissue; Lipoaspirates; Mesenchymal stern cells; Multi-lineage differentiation; Regenerative medicine; Tissue engineering
Departments, institutes and facilities:Fachbereich Angewandte Naturwissenschaften
Dewey Decimal Classification (DDC):600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit / 610 Medizin und Gesundheit
Entry in this database:2015/04/02